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ONCOLOGY, NUCLEAR MEDICINE AND TRANSPLANTOLOGY
Original Article
Jan 14, 2026 64 30

Combined Methods for Biliary Stricture Management: A Case Series

Zhandos Burkitbayev 1,
Azat Chinaliyaev 2,
Didar Khassenov 3 * ,
Kanat Batyrbekov 4,
Asset Kenzhin 5,
Tokan Sultanaliev 6,
Mansur Kassymov 7,
Aktolkyn Daumen 8,
Shaimerden Yedige 9
1 Chairman of the Board of Directors, National Research Oncology Center LLP, Astana, Kazakhstan2 Managing Director for Scientific and Educational Activities at the National Research Oncology Center LLP, Astana, Kazakhstan3 Department of Expert Endoscopy and Interventional Radiology, Interventional Radiologist, National Research Oncology Center LLP, Astana, Kazakhstan4 Head of Department Expert Endoscopy and Interventional Radiology, National Research Oncology Center LLP, Astana, Kazakhstan5 Senior Registrar, Department of Expert Endoscopy and Interventional Radiology, National Research Oncology Center LLP, Astana, Kazakhstan6 Chief Consultant Surgeon, National Research Oncology Center LLP, Astana, Kazakhstan7 Interventional Radiologist, Department of Expert Endoscopy and Interventional Radiology, National Research Oncology Center LLP, Astana, Kazakhstan8 Interventional Radiologist. Department of Expert Endoscopy and Interventional Radiology, National Research Oncology Center LLP, Astana, Kazakhstan9 Interventional radiologist, Department of Expert Endoscopy and Interventional Radiology, National Research Oncology Center LLP, Astana, Kazakhstan* Corresponding Author
Oncology, Nuclear Medicine and Transplantology, 2(1), 2026, onmt014, https://doi.org/10.63946/onmt/17741
Publication date: Jan 14, 2026
Full Text (PDF)

ABSTRACT

Abstract. Biliary strictures represent one of the most common complications after liver transplantation, occurring in 10-30% of recipients and significantly affecting patient quality of life and graft function. Combined hybrid approaches are increasingly widespread in contemporary practice.
Objective: To present a case series of successful application of combined methods for biliary stricture management in patients after liver transplantation and to analyze the efficacy and safety of these approaches.
Methods: A prospective observational study of three female patients (median age 57.0±7.8 years) after orthotopic liver transplantation with biliary strictures was conducted. All underwent a combined procedure using the rendezvous technique, integrating percutaneous transhepatic and endoscopic approaches with biliary stent placement.
Results: Technical success was achieved in 100% of cases (3/3). Clinical success with bilirubin reduction >50% was registered in all patients (3/3, 100%). Total bilirubin decreased from 71.3±22.8 μmol/L to 58.2±18.5 μmol/L by day 7 and to 32.4±8.6 μmol/L by day 30. No serious complications were registered (0/3, 0%). Mean hospitalization was 5.3±1.5 days (range 4-7 days). Mean procedure duration was 85±15 minutes.
Conclusion: The combined method demonstrated high technical feasibility (100%), clinical efficacy (100%), and a favorable safety profile with no serious complications, showing particular effectiveness in recurrent strictures. This approach can be considered as a promising alternative to isolated interventions in treating complex anastomotic biliary strictures.

KEYWORDS

Rendezvous Procedure Biliary Duct Stenting Postoperative Complications Percutaneous Transhepatic Cholangiography Endoscopic Intervention Hybrid Approachcomplications

CITATION (Vancouver)

Burkitbayev Z, Chinaliyaev A, Khassenov D, Batyrbekov K, Kenzhin A, Sultanaliev T, et al. Combined Methods for Biliary Stricture Management: A Case Series. Oncology, Nuclear Medicine and Transplantology. 2026;2(1):onmt014. https://doi.org/10.63946/onmt/17741
APA
Burkitbayev, Z., Chinaliyaev, A., Khassenov, D., Batyrbekov, K., Kenzhin, A., Sultanaliev, T., Kassymov, M., Daumen, A., & Yedige, S. (2026). Combined Methods for Biliary Stricture Management: A Case Series. Oncology, Nuclear Medicine and Transplantology, 2(1), onmt014. https://doi.org/10.63946/onmt/17741
Harvard
Burkitbayev, Z., Chinaliyaev, A., Khassenov, D., Batyrbekov, K., Kenzhin, A., Sultanaliev, T., . . . Yedige, S. (2026). Combined Methods for Biliary Stricture Management: A Case Series. Oncology, Nuclear Medicine and Transplantology, 2(1), onmt014. https://doi.org/10.63946/onmt/17741
AMA
Burkitbayev Z, Chinaliyaev A, Khassenov D, et al. Combined Methods for Biliary Stricture Management: A Case Series. Oncology, Nuclear Medicine and Transplantology. 2026;2(1), onmt014. https://doi.org/10.63946/onmt/17741
Chicago
Burkitbayev, Zhandos, Azat Chinaliyaev, Didar Khassenov, Kanat Batyrbekov, Asset Kenzhin, Tokan Sultanaliev, Mansur Kassymov, Aktolkyn Daumen, and Shaimerden Yedige. "Combined Methods for Biliary Stricture Management: A Case Series". Oncology, Nuclear Medicine and Transplantology 2026 2 no. 1 (2026): onmt014. https://doi.org/10.63946/onmt/17741
MLA
Burkitbayev, Zhandos et al. "Combined Methods for Biliary Stricture Management: A Case Series". Oncology, Nuclear Medicine and Transplantology, vol. 2, no. 1, 2026, onmt014. https://doi.org/10.63946/onmt/17741

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