Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection

Bakdaulet Yendibay; Akmaral Suleimenova; Aigerim Omirzakova; Lyazzat Mukhangaliyeva; Marzhan Nurlankyzy; Ramazan Ashirkhan; Wilfried Blanc; Daniele Tosi; Zhannat Ashikbayeva

doi:10.63946/onmt/19288

Congress Abstract

Sep 19, 2026 11 8

Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection

Bakdaulet Yendibay ¹ ² ^* ,

Akmaral Suleimenova ³ ⁴ ^* ,

Aigerim Omirzakova ¹,

Lyazzat Mukhangaliyeva ¹,

Marzhan Nurlankyzy ¹ ³,

Ramazan Ashirkhan ¹ ⁵,

Wilfried Blanc ⁶,

Daniele Tosi ¹ ⁵,

Zhannat Ashikbayeva ¹ ⁴

¹ Laboratory of Biosensors and Bioinstruments, Center for Life Sciences, National Laboratory Astana, Astana, Kazakhstan² Department of Chemical and Materials Engineering, School of Engineering, Nazarbayev University, Astana, Kazakhstan³ Nazarbayev University Research Administration, Astana, Kazakhstan⁴ Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan⁵ Department of Electrical and Computer Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana, Kazakhstan⁶ INPHYNI, CNRS, Université Côte d’Azur, Nice, France^* Corresponding Author

Oncology, Nuclear Medicine and Transplantology, 2(3, Suppl. 1), 2026, onmt_A6, https://doi.org/10.63946/onmt/19288

Publication date: Sep 19, 2026

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ABSTRACT

Introduction: The study of triple-negative breast cancer cells detection is one of the important research fields in modern biomedical engineering, due to its aggressive behavior and limited targeting options. One of the promising methods for cancer cell detection is using Molecularly Imprinted Polymers (MIPs) with polydopamine (PDA) as the primary polymer. The main idea of this combination is based on the properties of dopamine, as it shows good compatibility with cells, biomimicry, and biodegradability. By creating specific cell recognition cavities within this PDA-based MIP layer directly on the fiber surface, the platform shows high selectivity level performance.
Methods and Materials: Using bulk imprinting strategy, dopamine was polymerized under alkaline conditions, where pH was in range of 8.0-9.0. For control group, the non-imprinted polymers (NIPs) were prepared by mixing phosphate buffer solution (PBS) with PDA, while MIPs were functionalized with HCC1806 and MDA-MB231 cancer cell lines. During detection process, the response groups were divided into two categories: target and cross groups. Optical responses of these groups were determined by using fiber-optic interrogator at different cell concentrations and the morphology was evaluated via scanning electron microscopy.
Results and Conclusion: The provided optical fiber technology shows great detection, stability, and biocompatibility levels for novel technology and has a great potential for further development towards the label-free detection platforms’ integration.

KEYWORDS

Biosensing Techniques Polymers Cell Line Triple Negative Breast Neoplasms

CITATION (Vancouver)

Yendibay B, Suleimenova A, Omirzakova A, Mukhangaliyeva L, Nurlankyzy M, Ashirkhan R, et al. Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection. Oncology, Nuclear Medicine and Transplantology. 2026;2(3, Suppl. 1):onmt_A6. https://doi.org/10.63946/onmt/19288

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APA

Yendibay, B., Suleimenova, A., Omirzakova, A., Mukhangaliyeva, L., Nurlankyzy, M., Ashirkhan, R., Blanc, W., Tosi, D., & Ashikbayeva, Z. (2026). Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection. Oncology, Nuclear Medicine and Transplantology, 2(3, Suppl. 1), onmt_A6. https://doi.org/10.63946/onmt/19288

Harvard

Yendibay, B., Suleimenova, A., Omirzakova, A., Mukhangaliyeva, L., Nurlankyzy, M., Ashirkhan, R., . . . Ashikbayeva, Z. (2026). Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection. Oncology, Nuclear Medicine and Transplantology, 2(3, Suppl. 1), onmt_A6. https://doi.org/10.63946/onmt/19288

AMA

Yendibay B, Suleimenova A, Omirzakova A, et al. Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection. Oncology, Nuclear Medicine and Transplantology. 2026;2(3, Suppl. 1), onmt_A6. https://doi.org/10.63946/onmt/19288

Chicago

Yendibay, Bakdaulet, Akmaral Suleimenova, Aigerim Omirzakova, Lyazzat Mukhangaliyeva, Marzhan Nurlankyzy, Ramazan Ashirkhan, Wilfried Blanc, Daniele Tosi, and Zhannat Ashikbayeva. "Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection". Oncology, Nuclear Medicine and Transplantology 2026 2 no. 3, Suppl. 1 (2026): onmt_A6. https://doi.org/10.63946/onmt/19288

MLA

Yendibay, Bakdaulet et al. "Molecularly Imprinted Polymer Biofunctionalized Optical Fiber-Tip Quasi-Random Extrinsic Interferometer for Selective Triple-Negative Breast Cancer Cells Detection". Oncology, Nuclear Medicine and Transplantology, vol. 2, no. 3, Suppl. 1, 2026, onmt_A6. https://doi.org/10.63946/onmt/19288

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