Keyword: Lymphoma

ABSTRACT: Richter's syndrome (RS) is a malignant transformation of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) into a more aggressive lymphoid neoplasm. Typically, this term refers to the development of diffuse large B-cell lymphoma (DLBCL), which accounts for 90-95% of transformations. Much more rarely (in less than 5% of cases), the so-called Hodgkin’s variant of Richter’s syndrome occurs—transformation into classical Hodgkin’s lymphoma (HL). [1] The Hodgkin’s variant is characterized by the appearance of Reed-Sternberg cells or their variants in the infiltrate, surrounded by an inflammatory background typical of HL. It most often develops in patients with a long history of CLL/SLL, sometimes in the context of immunosuppression or after treatment with purine analogs and monoclonal antibodies. [2] The clinical picture of the Hodgkin’s variant of Richter’s syndrome typically includes pronounced B-symptoms (fever, night sweats, weight loss), rapidly progressing enlargement of lymph nodes and/or splenomegaly. Unlike the DLBCL variant, the course may be somewhat less aggressive; however, the prognosis remains unfavorable compared to primary Hodgkin’s lymphoma. [3]

ABSTRACT: Summary: The article presents the results of evaluating the diagnostic efficiency of ultrasound (US) in determining the extent of pathological processes in lymphoma patients. The study included 48 patients with Hodgkin’s and non-Hodgkin’s lymphoma who were hospitalized at the National Scientific Oncology Center from 2021 to 2024. All participants underwent comprehensive ultrasound of the abdominal parenchymal organs and lymph nodes using B-mode and Doppler imaging. The obtained data indicate high sensitivity and specificity of US in detecting liver, spleen, and abdominal lymph node involvement. Characteristic echographic signs of lymphatic conglomerates and associated complications such as ascites and exudative pleuritis were noted. Given the availability and safety of the method, US can be considered a key tool for primary diagnosis and lymphoma monitoring in clinical practice.
The purpose of the study: To evaluate the diagnostic efficiency of ultrasound (US) in assessing the extent of the disease in lymphoma.
Methods: A retrospective analysis of 48 medical records of patients with confirmed diagnoses of Hodgkin’s lymphoma (HL) and non-Hodgkin’s malignant lymphoma (NHL) who were treated at the National Scientific Oncology Center between 2021 and 2024. All patients underwent comprehensive abdominal ultrasound, pleural ultrasound, and lymph node imaging with Doppler.
Results: Pathological changes in lymph nodes, spleen, liver, and pleura were detected in all patients. In 60% of cases, the lymph node conglomerates appeared echonegative, while 5% showed signs of aggressive progression (undefined capsules, liquefaction). Typical echographic signs of diffuse and focal organ changes were observed.