First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study

V. V. Markelov; Yu. S. Osipov; E. K. Sokolova; S. V. Voloshin; Yu. A. Alexeeva; A. A. Sinkevich; P. A. Tereshenkova; N. A. Khasanova; D. I. Surtaeva; E. E. Zinina; O. S. Samoilova; N. V. Minaeva; N. N. Glonina; L. V. Anchukova; E. V. Patrakova; E. V. Zubkova; A. Yu. Kuvshinov; I. S. Zyuzgin; E. A. Ukrainchenko; M. A. Kolesnikova; I. S. Stepochkin; E. S. Pavlyuchenko; Yu. N. Vinogradova; T. S. Konstantinova; A. N. Gavrilenko; L. V. Fedorova; K. V. Lepik; V. V. Baikov; N. B. Mikhailova; A. D. Kulagin

Abstract

Oct 07, 2025 1 0

First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study

V. V. Markelov ¹ ^* ,

Yu. S. Osipov ² ^* ,

E. K. Sokolova ³ ^* ,

S. V. Voloshin ⁴ ^* ,

Yu. A. Alexeeva ² ^* ,

A. A. Sinkevich ⁵ ^* ,

P. A. Tereshenkova ⁶ ^* ,

N. A. Khasanova ⁷,

D. I. Surtaeva ⁸ ^* ,

E. E. Zinina ⁹ ^* ,

O. S. Samoilova ¹⁰ ^* ,

N. V. Minaeva ¹¹ ^* ,

N. N. Glonina ¹² ^* ,

L. V. Anchukova ¹³ ^* ,

E. V. Patrakova ¹⁴ ^* ,

E. V. Zubkova ¹⁵ ^* ,

A. Yu. Kuvshinov ¹⁶ ^* ,

I. S. Zyuzgin ¹⁷ ^* ,

E. A. Ukrainchenko ¹⁸ ^* ,

M. A. Kolesnikova ¹⁹ ^* ,

I. S. Stepochkin ²⁰ ^* ,

E. S. Pavlyuchenko ²¹ ^* ,

Yu. N. Vinogradova ²² ^* ,

T. S. Konstantinova ²³ ^* ,

A. N. Gavrilenko ¹ ^* ,

L. V. Fedorova ¹ ^* ,

K. V. Lepik ¹ ^* ,

V. V. Baikov ¹ ^* ,

N. B. Mikhailova ¹ ^* ,

A. D. Kulagin ¹ ^*

¹ R.M. Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantology, First Saint Petersburg State Medical University named after I.P. Pavlov, Saint Petersburg, Russia ² V.A. Almazov National Medical Research Center, Saint Petersburg, Russia ³ A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia ⁴ Leningrad Regional Clinical Hospital, Saint Petersburg, Russia ⁵ Regional Clinical Hospital, Krasnoyarsk, Russia ⁶ V.A. Baranov Republican Hospital, Petrozavodsk, Russia ⁷ City Clinical Hospital No. 31, Saint Petersburg, Russia ⁸ Regional Clinical Hospital, Barnaul, Russia ⁹ Surgut District Clinical Hospital, Surgut, Russia ¹⁰ N.A. Semashko Nizhny Novgorod Regional Clinical Hospital, Nizhny Novgorod, Russia ¹¹ Kirov Research Institute of Hematology and Blood Transfusion, Kirov, Russia ¹² Professor S.I. Sergeev Regional Clinical Hospital, Khabarovsk, Russia ¹³ Vologda Regional Clinical Hospital, Vologda, Russia ¹⁴ Vologda Regional Clinical Hospital No. 2, Cherepovets, Russia ¹⁵ Irkutsk Regional Oncological Dispensary, Irkutsk, Russia ¹⁶ Russian Research Institute of Hematology and Transfusiology, Saint Petersburg, Russia ¹⁷ N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg, Russia ¹⁸ City Clinical Hospital No. 17, Saint Petersburg, Russia ¹⁹ City Clinical Hospital No. 2, Novosibirsk, Russia ²⁰ Novgorod Regional Clinical Hospital, Veliky Novgorod, Russia ²¹ North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia ²² A.M. Granov Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg, Russia ²³ Sverdlovsk Regional Clinical Hospital No. 1, Yekaterinburg, Russia ^* Corresponding Author

Oncology, Nuclear Medicine and Transplantology, 1(Suppl. 1), 2025, onmt_A28

Publication date: Oct 07, 2025

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ABSTRACT

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal lymphomas with an aggressive clinical course. Currently, there are no systematic data available in the Russian Federation regarding treatment outcomes and prognosis in patients with PCNSL.
The aim of this study was to evaluate the clinical and epidemiological characteristics of patients with PCNSL, the current first-line therapeutic landscape, and treatment outcomes in real-world clinical practice.

KEYWORDS

Lymphoma CNS relapse PCNSL high-grade lymphoma DLBCL

CITATION (Vancouver)

Markelov VV, Osipov YS, Sokolova EK, Voloshin SV, Alexeeva YA, Sinkevich AA, et al. First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study. Oncology, Nuclear Medicine and Transplantology. 2025;1(Suppl. 1):onmt_A28.

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APA

Markelov, V. V., Osipov, Y. S., Sokolova, E. K., Voloshin, S. V., Alexeeva, Y. A., Sinkevich, A. A., Tereshenkova, P. A., Khasanova, N. A., Surtaeva, D. I., Zinina, E. E., Samoilova, O. S., Minaeva, N. V., Glonina, N. N., Anchukova, L. V., Patrakova, E. V., Zubkova, E. V., Kuvshinov, A. Y., Zyuzgin, I. S., Ukrainchenko, E. A., . . . Kulagin, A. D. (2025). First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study. Oncology, Nuclear Medicine and Transplantology, 1(Suppl. 1), onmt_A28.

Harvard

Markelov, V. V., Osipov, Y. S., Sokolova, E. K., Voloshin, S. V., Alexeeva, Y. A., Sinkevich, A. A., . . . Kulagin, A. D. (2025). First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study. Oncology, Nuclear Medicine and Transplantology, 1(Suppl. 1), onmt_A28.

AMA

Markelov VV, Osipov YS, Sokolova EK, et al. First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study. Oncology, Nuclear Medicine and Transplantology. 2025;1(Suppl. 1), onmt_A28.

Chicago

Markelov, V. V., Yu. S. Osipov, E. K. Sokolova, S. V. Voloshin, Yu. A. Alexeeva, A. A. Sinkevich, P. A. Tereshenkova, N. A. Khasanova, D. I. Surtaeva, E. E. Zinina, O. S. Samoilova, N. V. Minaeva, N. N. Glonina, L. V. Anchukova, E. V. Patrakova, E. V. Zubkova, A. Yu. Kuvshinov, I. S. Zyuzgin, E. A. Ukrainchenko, M. A. Kolesnikova, I. S. Stepochkin, E. S. Pavlyuchenko, Yu. N. Vinogradova, T. S. Konstantinova, A. N. Gavrilenko, L. V. Fedorova, K. V. Lepik, V. V. Baikov, N. B. Mikhailova, and A. D. Kulagin. "First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study". Oncology, Nuclear Medicine and Transplantology 2025 1 no. Suppl. 1 (2025): onmt_A28.

MLA

Markelov, V. V. et al. "First-Line Therapy of Primary Central Nervous System Lymphoma: A Russian Multicenter Study". Oncology, Nuclear Medicine and Transplantology, vol. 1, no. Suppl. 1, 2025, onmt_A28.

REFERENCES

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